Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | YAP1 | P46937 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.31 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | JAK1 | P23458 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.30 |
| ▸ | KAT7 | O95251 | 1/20 | 0.30 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL557670 | 0.94 | REN (0.64) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556610 | 0.93 | REN (0.64) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556137 | 0.92 | REN (0.62) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556555 | 0.91 | REN (0.59) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556433 | 0.91 | REN (0.60) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556596 | 0.86 | REN (0.54) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556537 | 0.84 | KCNH2 (0.72) | RENKCNH2CYP3A4TACR1ALK | |
| SCHEMBL556072 | 0.84 | REN (0.88) | RENKCNH2CYP3A4 | |
| SCHEMBL557192 | 0.83 | REN (0.59) | RENKCNH2CYP3A4 | |
| SCHEMBL556647 | 0.78 | REN (0.73) | RENKCNH2CYP3A4ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | REN 1/4885KCNH2 1198/4885CYP3A4 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.