Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 4/20 | 0.31 |
| ▸ | ERN1 | O75460 | 2/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567642 | 0.90 | SQOR (0.32) | MAPTSQORAPPCASP1 | |
| SCHEMBL5567645 | 0.90 | SQOR (0.32) | MAPTSQORAPPCASP1 | |
| SCHEMBL1750386 | 0.88 | NR1H2 (0.40) | MAPTALDH1A1KDM4E | |
| SCHEMBL5561371 | 0.87 | ROCK1 (0.33) | MAPTALDH1A1SQORCASP1CDC7 | |
| SCHEMBL5562265 | 0.84 | SQOR (0.36) | MAPTALDH1A1SQORCASP1CDC7 | |
| SCHEMBL3423349 | 0.81 | NR1H2 (0.40) | MAPTALDH1A1KDM4E | |
| SCHEMBL5567828 | 0.79 | KDM4E (0.40) | ALDH1A1KDM4E | |
| SCHEMBL5567692 | 0.79 | PARP1 (0.36) | — | |
| SCHEMBL1750961 | 0.78 | NR1H2 (0.40) | — | |
| SCHEMBL1750963 | 0.78 | NR1H2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753743-B1 | PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2015-03-04 | — | — | EP | disclosed |
| EP-1751141-A1 | NOVEL PYRIDAZINONE DERIVATIVES AS INHIBITORS OF CDK2 | Aventis Pharma S.A. (FR) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005111019-A1 | NOVEL PYRIDAZINONE DERIVATIVES AS INHIBITORS OF CDK2 | AVENTIS PHARMA S.A. (FR) | 2005-11-24 | — | — | WO | disclosed |