Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 1/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 3/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556337 | 1.00 | IAPP (0.59) | IAPPPTGS1PTGS2NFE2L2GLA | |
| SCHEMBL21986697 | 0.85 | IAPP (0.71) | IAPPPTGS1NFE2L2GLATDP1 | |
| SCHEMBL21986701 | 0.85 | IAPP (0.71) | IAPPPTGS1GLATDP1APP | |
| SCHEMBL30739991 | 0.85 | IAPP (0.71) | IAPPPTGS1GLATDP1APP | |
| SCHEMBL5335763 | 0.85 | IAPP (0.56) | IAPPPTGS1PTGS2NFE2L2GLA | |
| SCHEMBL21986845 | 0.85 | IAPP (0.71) | IAPPPTGS1GLATDP1APP | |
| SCHEMBL5335769 | 0.85 | IAPP (0.56) | IAPPPTGS1PTGS2NFE2L2GLA | |
| SCHEMBL21986702 | 0.85 | IAPP (0.71) | IAPPPTGS1NFE2L2GLATDP1 | |
| SCHEMBL3572968 | 0.84 | HSD11B1 (0.61) | PTGS2NFE2L2CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL3572966 | 0.84 | HSD11B1 (0.61) | PTGS2NFE2L2CYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
| US-20110150834-A1 | CRTH2 MODULATORS | WELLS FARGO BANK, NATIONAL ASSOCIATION | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | IAPP 2234/4885PTGS1 649/4885PTGS2 726/4885 |
| US-20110150834-A1 | CRTH2 MODULATORS | HRH2, HRH1, NR1H2 | IAPP 4418/4885PTGS1 100/4885PTGS2 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.