Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27381966 | 0.79 | GAA (0.37) | GAAALDH1A1CYP19A1 | |
| SCHEMBL5011462 | 0.76 | KMT2A (0.42) | ALDH1A1 | |
| SCHEMBL13994892 | 0.74 | USP2 (0.37) | GAAALDH1A1 | |
| SCHEMBL11538981 | 0.63 | GAA (0.43) | GAAHIF1AALDH1A1CYP2D6TSHR | |
| SCHEMBL27994026 | 0.62 | VEGFA (0.43) | ALDH1A1CYP2D6 | |
| SCHEMBL27784187 | 0.62 | VEGFA (0.43) | ALDH1A1CYP2D6 | |
| SCHEMBL28771275 | 0.61 | ALDH1A1 (0.40) | GAAALDH1A1CYP2D6TSHRCYP19A1 | |
| Hydrochloric Acid SCHEMBL4887656 | 0.59 | CASP3 (0.49) | ALDH1A1 | |
| SCHEMBL27362709 | 0.59 | GAA (0.47) | GAACYP2D6CYP19A1 | |
| Bromide SCHEMBL2446042 | 0.58 | HIF1A (0.74) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819123-B1 | 1,3-DIHYDRO-1-(PHENYLALKENYL)-2H-IMIDAZOL-2-ONE DERIVATIVES HAVING PDE IV AND CYTOKINE INHIBITING ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-12-12 | — | — | EP | disclosed |
| US-5952510-A | ENZYME INHIBITOR AS ANTIALLERGENS, ANTIINFLAMMATORY AGENT TREATING INFLAMMATION DISEASES, SKIN DISORDERS | JANSSEN PHARMACEUTICA, N.V. (BG) | 1999-09-14 | — | — | US | disclosed |