Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 11/20 | 0.47 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5563548 | 1.00 | ADRB2 (0.47) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL2962080 | 0.95 | ADRB2 (0.48) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL2962085 | 0.95 | ADRB2 (0.48) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL14204698 | 0.94 | ADRB2 (0.46) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL5140719 | 0.92 | ADRB2 (0.47) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL5140718 | 0.92 | ADRB2 (0.47) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL5037668 | 0.89 | ADRB2 (0.47) | ADRB2CASRTRPV1PDE4APDE4B | |
| SCHEMBL5566113 | 0.88 | ADRB3 (0.41) | ADRB2TRPV1PDE4APDE4BPDE4C | |
| SCHEMBL5566115 | 0.88 | ADRB3 (0.41) | ADRB2TRPV1PDE4APDE4BPDE4C | |
| SCHEMBL13842583 | 0.87 | ADRB2 (0.45) | ADRB2CASRTRPV1PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1708992-B1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LTD (GB) | 2007-08-08 | — | — | EP | disclosed |
| EP-1708992-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | Pfizer Limited (GB) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005080324-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES | PFIZER LIMITED (GB) | 2005-09-01 | — | — | WO | disclosed |