Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385950 | 0.82 | MAPT (0.46) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL16116481 | 0.80 | MAPT (0.50) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL5564416 | 0.80 | MAPT (0.61) | NPC1RAB9AMAPTL3MBTL1KDM4E | |
| SCHEMBL25284514 | 0.79 | NPC1 (0.60) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL31131887 | 0.77 | FYN (0.48) | MAPTTHRBAURKAPDE4DFYN | |
| SCHEMBL31131880 | 0.77 | FYN (0.48) | MAPTTHRBAURKAPDE4DFYN | |
| SCHEMBL14881614 | 0.76 | KMO (0.42) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL13263646 | 0.76 | NPC1 (0.53) | NPC1RAB9AMAPTL3MBTL1LMNA | |
| SCHEMBL7063800 | 0.73 | RAB9A (0.71) | NPC1RAB9AMAPTLMNAKDM4E | |
| SCHEMBL12789269 | 0.73 | NPC1 (0.56) | NPC1RAB9AMAPTL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1504004-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | SMITHKLINE BEECHAM CORP (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20050203106-A1 | Therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203106-A1 | Therapeutic compounds | ABCB1, PCSK9, ABCB11 | NPC1 8/4885RAB9A 1242/4885MAPT 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.