Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 8/20 | 0.60 |
| ▸ | NCF1 | P14598 | 5/20 | 0.57 |
| ▸ | HTR5A | P47898 | 3/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.57 |
| ▸ | HTR3B | O95264 | 2/20 | 0.57 |
| ▸ | HTR3A | P46098 | 2/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.57 |
| ▸ | HTR7 | P34969 | 1/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9904943 | 0.84 | PRKDC (0.53) | HTR6NCF1KDM4EALDH1A1HPGD | |
| SCHEMBL10994076 | 0.81 | NCF1 (0.51) | NCF1HTR3ALMNA | |
| SCHEMBL5369146 | 0.78 | HTR6 (0.68) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL10566917 | 0.75 | HTR6 (1.00) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL3166780 | 0.73 | HTR6 (1.00) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL240244 | 0.73 | HTR6 (1.00) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL29385724 | 0.73 | HTR6 (1.00) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL6959807 | 0.72 | HTR6 (0.72) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL722215 | 0.72 | BACE1 (0.55) | HTR6NCF1HTR5AHTR3EHTR3B | |
| SCHEMBL725003 | 0.72 | HTR6 (0.49) | HTR6NCF1HTR5AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492794-B1 | PIPERAZINE SUBSTITUTED ARYL BENZODIAZEPINES AND THEIR USE AS DOPAMINE RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PSYCHOTIC DISORDERS | LILLY CO ELI (US) | 2007-12-12 | — | — | EP | disclosed |