Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | F13A1 | P00488 | 1/20 | 0.32 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565253 | 0.81 | NPC1 (0.34) | RAB9ANPC1HRH3MAPTGAA | |
| SCHEMBL6454562 | 0.78 | F10 (0.40) | RAB9ANPC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5563297 | 0.75 | GAA (0.37) | RAB9ANPC1MAPTGAAALDH1A1 | |
| SCHEMBL5568419 | 0.71 | NPY2R (0.42) | RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL5564703 | 0.69 | ALDH1A1 (0.34) | RAB9ANPC1HRH3MAPTGAA | |
| SCHEMBL6454489 | 0.65 | CTSL (0.39) | RAB9ANPC1MAPTGAATP53 | |
| SCHEMBL6454350 | 0.65 | F10 (0.39) | RAB9ANPC1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6454183 | 0.63 | F10 (0.45) | RAB9ANPC1MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL5504268 | 0.62 | F10 (0.48) | — | |
| SCHEMBL5563698 | 0.61 | HRH3 (0.40) | RAB9ANPC1HRH3MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748997-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005111013-A1 | SUBSTITUTED THIOPHENE-2-CARBOXYLIC ACID AMIDES, THE PRODUCTION THEREOF AND THE USE THEREOF AS DRUGS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |