Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016182 | 0.93 | KMT2A (0.36) | HRH3KMT2AMEN1HPGDPAOX | |
| SCHEMBL356238 | 0.84 | KMT2A (0.38) | KMT2AMEN1HPGDCYP1A2CYP2C19 | |
| SCHEMBL2850740 | 0.78 | PAOX (0.37) | HRH3KMT2AMEN1HPGDPAOX | |
| SCHEMBL11269259 | 0.78 | KEAP1 (0.43) | HRH3KMT2AMEN1 | |
| SCHEMBL12550619 | 0.78 | GNAO1 (0.48) | KMT2AMEN1CNR2 | |
| SCHEMBL1097457 | 0.77 | KMT2A (0.37) | HRH3KMT2AMEN1HPGDPAOX | |
| SCHEMBL12550641 | 0.77 | GNAO1 (0.52) | — | |
| SCHEMBL12550633 | 0.77 | PAOX (0.40) | HRH3KMT2AMEN1HPGDPAOX | |
| SCHEMBL12550618 | 0.77 | GNAO1 (0.52) | — | |
| SCHEMBL12550634 | 0.77 | PAOX (0.40) | HRH3KMT2AMEN1HPGDPAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751165-A1 | 4-SUBSTITUTED 1,5-DIHYDRO-PYRIDO(3,2-B)INDOL-2-ONES | Tibotec Pharmaceuticals Ltd. (IE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005111044-A1 | 4-SUBSTITUTED-1,5-DIHYDRO-PYRIDO[3,2-B]INDOL-2-ONES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-11-24 | — | — | WO | disclosed |