Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566129 | 0.89 | P2RX7 (0.46) | P2RX7ABCB11THRB | |
| Benzoic Acid Hydrazide SCHEMBL6440127 | 0.88 | P2RX7 (0.46) | P2RX7ABCB11THRBPDE2AMAPT | |
| SCHEMBL5566953 | 0.86 | P2RX7 (0.44) | P2RX7ABCB11THRBPDE2A | |
| SCHEMBL5566088 | 0.85 | P2RX7 (0.46) | P2RX7ABCB11THRBPDE2A | |
| SCHEMBL5566710 | 0.83 | P2RX7 (0.41) | P2RX7ABCB11THRBPDE2AIDO1 | |
| SCHEMBL10673166 | 0.79 | P2RX7 (0.42) | P2RX7ABCB11THRBPDE2AIDO1 | |
| SCHEMBL5560395 | 0.76 | MEN1 (0.43) | P2RX7ABCB11THRBPDE2AIDO1 | |
| SCHEMBL5567074 | 0.76 | THRB (0.39) | P2RX7ABCB11THRB | |
| SCHEMBL6478877 | 0.76 | P2RX7 (0.45) | P2RX7ABCB11THRB | |
| SCHEMBL6478617 | 0.75 | MEN1 (0.47) | P2RX7ABCB11THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000040-B1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-13 | — | — | EP | disclosed |
| EP-1000040-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999002505-A1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1999-01-21 | — | — | WO | disclosed |