Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5567074 | 0.91 | THRB (0.39) | P2RX7ABCB11THRBMEN1NR1I2 | |
| SCHEMBL5566953 | 0.89 | P2RX7 (0.44) | P2RX7ABCB11THRBMEN1NR1I2 | |
| SCHEMBL5566088 | 0.89 | P2RX7 (0.46) | P2RX7ABCB11THRBMEN1NR1I2 | |
| SCHEMBL5561098 | 0.88 | MEN1 (0.48) | P2RX7ABCB11THRBMEN1NR1I2 | |
| SCHEMBL5566124 | 0.86 | THRB (0.35) | P2RX7THRBMEN1KMT2APDE2A | |
| SCHEMBL10673166 | 0.85 | P2RX7 (0.42) | P2RX7ABCB11THRBMEN1NR1I2 | |
| Benzoic Acid Hydrazide SCHEMBL6440127 | 0.84 | P2RX7 (0.46) | P2RX7ABCB11THRBPDE2A | |
| SCHEMBL5564868 | 0.83 | P2RX7 (0.45) | P2RX7ABCB11THRBIDO1TDO2 | |
| SCHEMBL5560395 | 0.81 | MEN1 (0.43) | P2RX7ABCB11THRBMEN1NR1I2 | |
| SCHEMBL5565457 | 0.80 | MEN1 (0.42) | P2RX7ABCB11THRBMEN1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000040-B1 | IL-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-13 | — | — | EP | disclosed |
| US-6867207-B2 | IL-5 inhibiting 6-azauracil derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-15 | — | — | US | disclosed |
| US-20040167333-A1 | Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs | LACRAMPE JEAN FERNAND ARMAND (FR) | 2004-08-26 | — | — | US | disclosed |
| US-20020072603-A1 | Novel IL-5 inhibiting 6-azauracil derivatives | LACRAMPE JEAN FERNAND ARMAND (FR) | 2002-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167333-A1 | Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs | IL6ST, CXCR5, ALOX5 | P2RX7 316/4885ABCB11 3042/4885THRB 481/4885 |
| US-20020072603-A1 | Novel IL-5 inhibiting 6-azauracil derivatives | IL6ST, ALOX5, IL5 | P2RX7 713/4885ABCB11 3215/4885THRB 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.