Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564443 | 0.80 | NPSR1 (0.46) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL6462245 | 0.79 | KDM4E (0.45) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL5566265 | 0.79 | HSD17B2 (0.53) | HPGDTSHRL3MBTL1HSD17B10KDM4E | |
| SCHEMBL6455153 | 0.77 | ALDH1A1 (0.50) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL70702 | 0.76 | DAO (0.63) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL5565065 | 0.76 | NPSR1 (0.42) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL6454902 | 0.76 | ALDH1A1 (0.46) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL1588116 | 0.75 | HPGD (0.51) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL5557107 | 0.75 | NPSR1 (0.43) | NPSR1MAPK1ATMHPGDTSHR | |
| SCHEMBL798405 | 0.72 | TSHR (0.40) | NPSR1MAPK1HPGDTSHRPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |