Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564443 | 0.85 | NPSR1 (0.46) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL6455153 | 0.84 | ALDH1A1 (0.50) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5563984 | 0.81 | HSD17B2 (0.42) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5565742 | 0.80 | KDM4E (0.46) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL6454902 | 0.78 | ALDH1A1 (0.46) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5557107 | 0.77 | NPSR1 (0.43) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5565183 | 0.76 | NPSR1 (0.42) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5565995 | 0.75 | KDM4E (0.48) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL6462245 | 0.73 | KDM4E (0.45) | NPSR1TSHRMAPK1HPGDATM | |
| SCHEMBL5561977 | 0.73 | ALDH1A1 (0.56) | NPSR1TSHRMAPK1HPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |