Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.44 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5564448 | 0.80 | NPC1 (0.56) | NPSR1GAARXFP1KDM4EESR1 | |
| SCHEMBL6462246 | 0.79 | RAB9A (0.66) | GAAKDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL2001834 | 0.77 | NPSR1 (0.50) | NPSR1GAARXFP1KDM4EESR1 | |
| SCHEMBL1587972 | 0.77 | HPGD (0.50) | NPSR1GAARXFP1KDM4EESR1 | |
| SCHEMBL6455155 | 0.77 | HDAC3 (0.65) | GAANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5566270 | 0.77 | HDAC6 (0.47) | NPSR1GAAKDM4ENPC1RAB9A | |
| SCHEMBL70702 | 0.76 | DAO (0.63) | NPSR1GAARXFP1KDM4EESR1 | |
| SCHEMBL5565068 | 0.76 | NPC1 (0.51) | GAANPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6454906 | 0.76 | NPC1 (0.58) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL2161403 | 0.75 | LMNA (0.40) | NPSR1NPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |