Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 3/20 | 0.45 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.45 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 2/20 | 0.45 |
| ▸ | HSPE1 | P61604 | 2/20 | 0.45 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31478925 | 1.00 | MEN1 (0.52) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL31478890 | 0.87 | MEN1 (0.55) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL4726823 | 0.87 | MEN1 (0.55) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL4775594 | 0.80 | SLC20A2 (0.51) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL4846633 | 0.80 | SLC20A2 (0.49) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL30304724 | 0.78 | AXL (0.47) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL4780564 | 0.78 | AXL (0.47) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL4781358 | 0.76 | MEN1 (0.55) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL31478924 | 0.76 | SLC40A1 (0.57) | MEN1KMT2AGAASLC40A1LMNA | |
| SCHEMBL3078414 | 0.76 | SLC40A1 (0.57) | MEN1KMT2AGAASLC40A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2007-01-04 | — | — | US | disclosed |
| US-7119112-B2 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | ICAGEN, INC. (US) | 2006-05-04 | — | — | US | disclosed |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | ICAGEN, INC. | 2004-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094721-A9 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | MEN1 2417/4885KMT2A 441/4885GAA 1191/4885 |
| US-20040106613-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | MEN1 2417/4885KMT2A 441/4885GAA 1191/4885 |
| US-20070004784-A1 | Sulfonamides as potassium channel blockers | KCNJ2, KCNJ1, KCNJ11 | MEN1 2417/4885KMT2A 441/4885GAA 1191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.