Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 7/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | STS | P08842 | 4/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.45 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565698 | 0.87 | HSD17B3 (0.57) | HSD17B3THRATHRBSTSUSP2 | |
| SCHEMBL5078148 | 0.86 | HDAC3 (0.55) | ALDH1A1LMNAMAPTTSHRHTT | |
| SCHEMBL27318923 | 0.85 | HSD17B3 (0.63) | HSD17B3THRATHRBSTSALDH1A1 | |
| SCHEMBL29180345 | 0.84 | HSD17B3 (0.45) | HSD17B3THRATHRBALDH1A1LMNA | |
| SCHEMBL7390784 | 0.84 | HSD17B3 (0.45) | HSD17B3THRATHRBALDH1A1LMNA | |
| SCHEMBL10897477 | 0.83 | HSD17B3 (0.57) | HSD17B3HTR7THRATHRBSTS | |
| SCHEMBL23748657 | 0.83 | HSD17B3 (0.54) | HSD17B3HTR7THRATHRBSTS | |
| SCHEMBL27939427 | 0.83 | HSD17B3 (0.57) | HSD17B3HTR7THRATHRBSTS | |
| SCHEMBL18753070 | 0.82 | HSD17B3 (0.84) | HSD17B3HTR7THRATHRBSTS | |
| SCHEMBL5660140 | 0.82 | LMNA (0.48) | HSD17B3THRATHRBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2734517-B1 | BENZAMIDES | MERCK PATENT GMBH (DE) | 2017-08-30 | — | — | EP | disclosed |
| EP-1745004-B1 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2016-05-18 | — | — | EP | disclosed |
| US-8445514-B2 | Urotensin II receptor antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2013-05-21 | — | — | US | disclosed |
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | KINNEY WILLIAM A | 2011-11-03 | — | — | US | disclosed |
| EP-1745004-A4 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECH INC (US) | 2007-05-09 | — | — | EP | disclosed |
| EP-1745004-A2 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | Emisphere Technologies, Inc. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005117854-A2 | ARYL KETONE COMPOUNDS AND COMPOSITIONS FOR DELIVERING ACTIVE AGENTS | EMISPHERE TECHNOLOGIES, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269768-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | UTS2R, BDKRB2, AGTR2 | HSD17B3 2767/4885HTR7 670/4885THRA 460/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.