Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methyl Salicylate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | CA1 | P00915 | 5/20 | 0.55 |
| ▸ | CA2 | P00918 | 5/20 | 0.55 |
| ▸ | CA9 | Q16790 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | CA12 | O43570 | 4/20 | 0.55 |
| ▸ | CA7 | P43166 | 4/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.55 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29440754 | 0.89 | ALDH1A1 (0.69) | LMNATSHRALDH1A1CA1CA2 | |
| Salicylic Acid SCHEMBL4154929 | 0.89 | ALDH1A1 (0.69) | LMNATSHRALDH1A1CA1CA2 | |
| Methyl Salicylate SCHEMBL31387071 | 0.89 | TSHR (0.85) | LMNATSHRALDH1A1CA1CA2 | |
| SCHEMBL20582600 | 0.87 | LMNA (0.50) | LMNATSHRALDH1A1HPGDKDM4E | |
| Salicylic Acid SCHEMBL29028986 | 0.87 | ALDH1A1 (0.67) | LMNATSHRALDH1A1CA1CA2 | |
| SCHEMBL5565286 | 0.84 | LMNA (0.61) | LMNATSHRALDH1A1HPGDKDM4E | |
| Salicylic Acid SCHEMBL28736818 | 0.84 | ALDH1A1 (0.62) | LMNATSHRALDH1A1CA1CA2 | |
| Salicylic Acid SCHEMBL29817834 | 0.84 | ALDH1A1 (0.62) | LMNATSHRALDH1A1CA1CA2 | |
| Methyl Salicylate SCHEMBL27586961 | 0.84 | LMNA (0.88) | LMNATSHRALDH1A1CA1CA2 | |
| Methyl Salicylate SCHEMBL4199244 | 0.83 | TSHR (0.96) | LMNATSHRALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007100910-A2 | TRANSDERMAL PATCHES CONTAINING A NITRIC OXIDE-DONOR AND A SECOND ACTIVE AGENT AND ASSOCIATED METHODS | CURE THERAPEUTICS, INC. (US) | 2007-09-07 | — | — | WO | claimed |
| US-20070059351-A1 | Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods | CURE THERAPEUTICS, INC. | 2007-03-15 | — | — | US | claimed |
| WO-2007100910-A2 | TRANSDERMAL PATCHES CONTAINING A NITRIC OXIDE-DONOR AND A SECOND ACTIVE AGENT AND ASSOCIATED METHODS | CURE THERAPEUTICS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| US-20070059351-A1 | Transdermal patches containing a nitric oxide-donor and a second active agent and associated methods | CURE THERAPEUTICS, INC. | 2007-03-15 | — | — | US | disclosed |