Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5566000 | 0.90 | SMN1; SMN2 (0.50) | SMN1; SMN2NPC1RAB9AHTTHDAC3 | |
| SCHEMBL5565068 | 0.80 | NPC1 (0.51) | SMN1; SMN2NPC1RAB9AHTTHDAC3 | |
| SCHEMBL6455155 | 0.79 | HDAC3 (0.65) | SMN1; SMN2NPC1RAB9AHDAC3HDAC4 | |
| SCHEMBL5563990 | 0.78 | CNR1 (0.53) | RAB9AHDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL6462246 | 0.78 | RAB9A (0.66) | SMN1; SMN2NPC1RAB9AMAPTLMNA | |
| SCHEMBL5049377 | 0.75 | PRKACA (0.53) | NPC1HDAC3HDAC4HDAC1HDAC6 | |
| SCHEMBL1587804 | 0.74 | RAB9A (0.53) | SMN1; SMN2NPC1RAB9AHDAC3HDAC4 | |
| SCHEMBL6454906 | 0.73 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AHDAC3HDAC4 | |
| SCHEMBL5560544 | 0.73 | MAPT (0.48) | SMN1; SMN2NPC1RAB9AHDAC3HDAC4 | |
| SCHEMBL5565742 | 0.72 | KDM4E (0.46) | NPC1RAB9AHDAC3HDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |