Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 9/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5565995 | 0.90 | KDM4E (0.48) | KDM4ENPC1RAB9AALDH1A1HSD17B2 | |
| SCHEMBL5565065 | 0.80 | NPSR1 (0.42) | KDM4ERAB9AMAPTNPSR1L3MBTL1 | |
| SCHEMBL6455153 | 0.79 | ALDH1A1 (0.50) | KDM4EALDH1A1MAPTNPSR1L3MBTL1 | |
| SCHEMBL5563984 | 0.78 | HSD17B2 (0.42) | HSD17B2HSD17B1NPSR1L3MBTL1HPGD | |
| SCHEMBL6462245 | 0.78 | KDM4E (0.45) | KDM4ENPC1RAB9AALDH1A1MAPT | |
| SCHEMBL6454902 | 0.73 | ALDH1A1 (0.46) | KDM4EALDH1A1HSD17B2HSD17B1MAPT | |
| SCHEMBL5565747 | 0.72 | SMN1; SMN2 (0.50) | NPC1RAB9AMAPTHDAC3HDAC1 | |
| SCHEMBL5564443 | 0.72 | NPSR1 (0.46) | ALDH1A1MAPTNPSR1L3MBTL1HPGD | |
| SCHEMBL5557107 | 0.72 | NPSR1 (0.43) | ALDH1A1MAPTNPSR1L3MBTL1HPGD | |
| SCHEMBL4579984 | 0.71 | NPC1 (0.46) | KDM4ENPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778683-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-05-02 | — | — | EP | disclosed |
| WO-2005121134-A1 | THIOPHENE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-12-22 | — | — | WO | disclosed |