Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6694322 | 0.81 | SIGMAR1 (0.50) | SIGMAR1POLBRENRXFP1OPRD1 | |
| SCHEMBL7747319 | 0.78 | SIGMAR1 (0.41) | SIGMAR1POLBTACR1RENRXFP1 | |
| SCHEMBL7749574 | 0.77 | OPRD1 (0.41) | SIGMAR1OPRM1POLBTACR1REN | |
| SCHEMBL4759640 | 0.77 | GAA (0.58) | SIGMAR1POLBRENRXFP1KMT2A | |
| SCHEMBL5570991 | 0.77 | SIGMAR1 (0.47) | SIGMAR1OPRM1POLBRENOPRD1 | |
| SCHEMBL7388960 | 0.77 | ALDH1A1 (0.61) | SIGMAR1POLBTACR1RXFP1KMT2A | |
| SCHEMBL7747270 | 0.77 | SIGMAR1 (0.40) | SIGMAR1POLBTACR1RENRXFP1 | |
| SCHEMBL7746739 | 0.76 | ALDH1A1 (0.36) | SIGMAR1OPRM1POLBTACR1REN | |
| SCHEMBL4421969 | 0.76 | TACR1 (0.53) | SIGMAR1TACR1CHRM1CHRM3KMT2A | |
| Hydrochloric Acid SCHEMBL4711746 | 0.76 | GAA (0.57) | SIGMAR1POLBRENRXFP1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262197-B2 | Phospholipase C inhibitors for use in treating inflammatory disorders | JANSSEN PHARMACEUTICA, N.V (BE) | 2007-08-28 | — | — | US | disclosed |