Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.42 |
| ▸ | CTSS | P25774 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908254 | 0.86 | CTSK (0.43) | CTSKCTSSATMMLYCDCTSL | |
| SCHEMBL11115346 | 0.81 | SMN1; SMN2 (0.44) | CTSKCTSSATMCYP2C9CYP2C19 | |
| SCHEMBL3134758 | 0.79 | PPARG (0.41) | CTSKCTSSATMMLYCDCTSL | |
| SCHEMBL8661223 | 0.77 | PPARA (0.41) | CTSKCTSSATMKMT2ACTSL | |
| SCHEMBL7315031 | 0.77 | CTSS (0.43) | CTSKCTSSMEN1KMT2ACTSL | |
| SCHEMBL1624311 | 0.77 | SMN1; SMN2 (0.51) | MEN1CYP3A4CYP2C9CYP2C19KMT2A | |
| SCHEMBL14085922 | 0.75 | CTSS (0.53) | CTSKCTSSATMMEN1KMT2A | |
| SCHEMBL8416662 | 0.75 | CTSK (0.46) | CTSKCTSSATMMEN1KMT2A | |
| SCHEMBL1342159 | 0.74 | PPARA (0.50) | CTSKCTSSCTSLCTSBPPARA | |
| SCHEMBL1341688 | 0.74 | PPARA (0.50) | CTSKCTSSCTSLCTSBPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7265096-B2 | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof | XENOPORT, INC. (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1567169-A2 | GEMCITABINE PRODRUGS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Xenoport, Inc. (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20040142857-A1 | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof | XENOPORT, INC. | 2004-07-22 | — | — | US | disclosed |
| WO-2004041203-A2 | GEMCITABINE PRODRUGS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | XENOPORT, INC. (US) | 2004-05-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142857-A1 | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof | TYMP, GDA, GCG | CTSK 1533/4885CTSS 1486/4885ATM 1946/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.