Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.31 |
| ▸ | CTH | P32929 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12022925 | 0.83 | TSHR (0.41) | TSHRTDP1PKM | |
| SCHEMBL7721748 | 0.80 | LMNA (0.64) | TSHRHSD17B10LMNAKMT2ATDP1 | |
| SCHEMBL7721691 | 0.80 | CYP2D6 (0.48) | TSHRHSD17B10LMNAKMT2ATDP1 | |
| SCHEMBL7720625 | 0.78 | CYP2D6 (0.46) | TSHRHSD17B10LMNAKMT2ATDP1 | |
| SCHEMBL161464 | 0.77 | — | — | |
| SCHEMBL12475448 | 0.77 | — | — | |
| SCHEMBL2185204 | 0.77 | TSHR (0.52) | TSHRHSD17B10LMNAKMT2ATDP1 | |
| SCHEMBL1251621 | 0.77 | LMNA (0.41) | TSHRHSD17B10LMNAKMT2ATDP1 | |
| SCHEMBL949060 | 0.75 | TSHR (0.35) | TSHRHSD17B10KMT2ATDP1PKM | |
| SCHEMBL7719757 | 0.75 | BHMT (0.49) | TSHRHSD17B10LMNAKMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1737886-A2 | COMPOUNDS THAT BLOCK THE C5A RECEPTOR AND THEIR USE IN THERAPY | Alligator Bioscience AB (publ) (SE) | 2007-01-03 | — | — | EP | disclosed |
| WO-2005100385-A2 | COMPOUNDS THAT BLOCK THE C5A RECEPTOR AND THEIR USE IN THERAPY | ALLIGATOR BIOSCIENCE AB (PUBL) (SE) | 2005-10-27 | — | — | WO | disclosed |
| WO-2003006048-A1 | COMBINATION OF CHIPS (CHEMOTAXIS INHIBITING PROTEIN FROM STAPHYLOCOCCUS AUREUS)-BASED COMPOUNDS | JARI PHARMACEUTICALS B.V. (NL) | 2003-01-23 | — | — | WO | disclosed |