Sugi Predict

Sugi Predict / Compounds / SCHEMBL5566846

SCHEMBL5566846

SCHEMBL5566846

CC(=O)NNC(=O)C(c1ccc(Cl)cc1)c1ccc(-n2ncc(=O)[nH]c2=O)cc1Cl

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.50
▸ NR1I2 O75469 1/20 0.50
▸ KMT2A Q03164 1/20 0.50
▸ P2RX7 Q99572 11/20 0.46
▸ ABCB11 O95342 1/20 0.41
▸ THRB P10828 8/20 0.38
▸ THRA P10827 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10394520 0.89 MEN1 (0.53) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL5567087 0.87 MEN1 (0.47) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL9823506 0.85 MEN1 (0.53) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL5567160 0.85 MEN1 (0.56) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL6490492 0.85 MEN1 (0.56) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL9823423 0.84 MEN1 (0.55) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL9823812 0.83 MEN1 (0.48) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL5561466 0.81 MEN1 (0.54) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL5565462 0.81 P2RX7 (0.47) MEN1NR1I2KMT2AP2RX7ABCB11
SCHEMBL6480171 0.80 MEN1 (0.49) MEN1NR1I2KMT2AP2RX7ABCB11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1000040-B1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2007-06-13 — — EP disclosed
US-20050090495-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs LACRAMPE JEAN FERNAND ARMAND (FR) 2005-04-28 — — US disclosed
US-6867207-B2 IL-5 inhibiting 6-azauracil derivatives JANSSEN PHARMACEUTICA N.V. (BE) 2005-03-15 — — US disclosed
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs LACRAMPE JEAN FERNAND ARMAND (FR) 2004-08-26 — — US disclosed
US-20020072603-A1 Novel IL-5 inhibiting 6-azauracil derivatives LACRAMPE JEAN FERNAND ARMAND (FR) 2002-06-13 — — US disclosed
EP-1000040-A1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2000-05-17 — — EP disclosed
WO-1999002505-A1 IL-5 INHIBITING 6-AZAURACIL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1999-01-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040167333-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs IL6ST, CXCR5, ALOX5 MEN1 4239/4885NR1I2 203/4885KMT2A 4336/4885
US-20050090495-A1 Novel IL-5 inhibiting 6-azauracil derivatives for marking and identifying receptors and imaging organs CXCR5, HCAR3, IL6ST MEN1 3111/4885NR1I2 211/4885KMT2A 4590/4885
US-20020072603-A1 Novel IL-5 inhibiting 6-azauracil derivatives IL6ST, ALOX5, IL5 MEN1 4683/4885NR1I2 266/4885KMT2A 3274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.