Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IL1B | P01584 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14497661 | 0.94 | KDM4E (0.62) | KDM4EPKMRECQLSTSALDH1A1 | |
| SCHEMBL5571955 | 0.91 | ACKR3 (0.49) | KDM4EPKMRECQLALDH1A1GAA | |
| SCHEMBL4774938 | 0.88 | RECQL (0.49) | KDM4EPKMRECQLALDH1A1GAA | |
| SCHEMBL4777534 | 0.86 | USP30 (0.52) | STSALDH1A1 | |
| SCHEMBL5571649 | 0.86 | ALDH1A1 (0.47) | ALDH1A1GAALMNADRD2 | |
| SCHEMBL4773589 | 0.86 | RECQL (0.52) | KDM4EPKMRECQLSTSALDH1A1 | |
| SCHEMBL4768022 | 0.84 | STS (0.50) | STSALDH1A1GPR119MAPTLMNA | |
| SCHEMBL5571930 | 0.81 | ALDH1A1 (0.56) | KDM4EPKMRECQLALDH1A1GAA | |
| SCHEMBL5572116 | 0.81 | ALDH1A1 (0.42) | RECQLSTSALDH1A1GAAMAPT | |
| SCHEMBL4767621 | 0.81 | RECQL (0.49) | KDM4ERECQLALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-14 | — | — | US | claimed |
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-06-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135435-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | KDM4E 3267/4885PKM 932/4885RECQL 139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.