Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 10/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.46 |
| ▸ | USP2 | O75604 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17008457 | 1.00 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL2633405 | 0.83 | L3MBTL3 (0.49) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL2110081 | 0.83 | L3MBTL3 (0.49) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| Hydrochloric Acid SCHEMBL16059731 | 0.82 | TSHR (0.50) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL23063180 | 0.77 | L3MBTL3 (0.37) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| Trifluoroacetic Acid SCHEMBL30567860 | 0.75 | L3MBTL3 (0.49) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL13931106 | 0.73 | L3MBTL3 (0.44) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL24718107 | 0.73 | ALDH1A1 (0.41) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL346460 | 0.72 | CYP2D6 (0.39) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 | |
| SCHEMBL13931105 | 0.72 | HRH3 (0.45) | ALDH1A1CYP3A4CYP2D6CYP1A2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812005-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | Incyte Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006053024-A2 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2006-05-18 | — | — | WO | disclosed |