Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31708217 | 0.86 | HSD17B10 (0.44) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL4491902 | 0.82 | KMT2A (0.44) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL4501819 | 0.82 | KMT2A (0.44) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL15746491 | 0.79 | DDB1 (0.51) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL875841 | 0.79 | MAPK1 (0.58) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL873535 | 0.79 | DDB1 (0.51) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL877603 | 0.79 | POLB (0.53) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL7981025 | 0.78 | MAPK1 (0.56) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL872472 | 0.75 | DDB1 (0.55) | KMT2AALDH1A1MAPK1POLBHSD17B10 | |
| SCHEMBL14517050 | 0.75 | ALDH1A1 (0.56) | KMT2AALDH1A1MAPK1POLBHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226906-B2 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| WO-2006023452-A2 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES | ARRAY BIOPHARMA INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060035821-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
| US-20060035822-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035821-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | TSLP, CHP1, IL2 | KMT2A 4822/4885ALDH1A1 3651/4885MAPK1 4671/4885 |
| US-20060035822-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | TSLP, CHP1, IL2 | KMT2A 4822/4885ALDH1A1 3651/4885MAPK1 4671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.