Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 4/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776729 | 0.89 | MAPT (0.46) | POLBL3MBTL1MAPTPTGDR2KMT2A | |
| SCHEMBL306788 | 0.83 | TRPM8 (0.45) | POLBL3MBTL1MAPTPTGDR2MEP1B | |
| SCHEMBL125827 | 0.82 | CYP3A4 (0.42) | POLBL3MBTL1MAPTPTGDR2MEP1B | |
| SCHEMBL125851 | 0.80 | MAPT (0.42) | POLBL3MBTL1MAPTPTGDR2KMT2A | |
| SCHEMBL125850 | 0.79 | POLB (0.44) | POLBL3MBTL1MAPTPTGDR2KMT2A | |
| SCHEMBL306366 | 0.77 | POLB (0.43) | POLBL3MBTL1MAPTKMT2AHSD17B10 | |
| SCHEMBL21999845 | 0.76 | POLB (0.42) | POLBL3MBTL1MAPTKMT2AHSD17B10 | |
| SCHEMBL10223024 | 0.75 | TRPM8 (0.39) | POLBL3MBTL1MAPTLMNAMEP1B | |
| SCHEMBL306011 | 0.75 | TRPM8 (0.44) | POLBL3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL12594275 | 0.75 | LMNA (0.44) | POLBL3MBTL1MAPTPTGDR2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |