Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL125851 | 0.89 | MAPT (0.42) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL5569866 | 0.89 | POLB (0.44) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL125850 | 0.88 | POLB (0.44) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL306788 | 0.87 | TRPM8 (0.45) | MAPTPTGDR2POLBL3MBTL1TRPM8 | |
| SCHEMBL125827 | 0.86 | CYP3A4 (0.42) | MAPTPTGDR2POLBL3MBTL1TRPM8 | |
| SCHEMBL12594275 | 0.85 | LMNA (0.44) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL18707932 | 0.80 | CYP3A4 (0.46) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL18714370 | 0.80 | CYP3A4 (0.46) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL10223025 | 0.80 | ALDH1A1 (0.45) | MAPTPTGDR2POLBL3MBTL1LMNA | |
| SCHEMBL15259946 | 0.79 | MAPT (0.37) | MAPTPTGDR2POLBL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |