Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN4 | O15554 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1316739 | 0.71 | GAA (0.38) | KCNN4LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL1316741 | 0.71 | GAA (0.38) | KCNN4LMNAHPGDALDH1A1KDM4E | |
| SCHEMBL27939611 | 0.70 | ALDH1A1 (0.36) | KCNN4LMNAHPGDALDH1A1MEN1 | |
| SCHEMBL28810547 | 0.70 | ALDH1A1 (0.36) | KCNN4LMNAHPGDALDH1A1MEN1 | |
| SCHEMBL31414989 | 0.66 | KCNN4 (0.52) | KCNN4LMNAKCNE1KCNQ1HPGD | |
| SCHEMBL17420795 | 0.66 | KCNN4 (0.52) | KCNN4LMNAKCNE1KCNQ1HPGD | |
| SCHEMBL3818506 | 0.66 | KCNN4 (0.52) | KCNN4KCNE1KCNQ1ALDH1A1KMT2A | |
| SCHEMBL7178206 | 0.65 | KCNN4 (0.50) | KCNN4KCNE1KCNQ1ALDH1A1KMT2A | |
| SCHEMBL30501782 | 0.65 | KCNN4 (0.50) | KCNN4KCNE1KCNQ1ALDH1A1KMT2A | |
| SCHEMBL1239901 | 0.65 | KCNN4 (0.50) | KCNN4KCNE1KCNQ1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841738-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | Athersys, Inc. (US) | 2007-10-10 | — | — | EP | disclosed |
| WO-2007081299-A2 | TRICYCLIC INDENO-PYRROLE DERIVATIVES AS SEROTONIN RECEPTOR MODULATORS | ATHERSYS, INC. (US) | 2007-07-19 | — | — | WO | disclosed |