Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | TPO | P07202 | 1/20 | 0.51 |
| ▸ | EPX | P11678 | 1/20 | 0.51 |
| ▸ | LPO | P22079 | 1/20 | 0.51 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PNLIP | P16233 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570386 | 0.82 | EGFR (0.38) | MPOTPOEPXLPOKDM4E | |
| SCHEMBL159190 | 0.82 | MPO (0.51) | MPOTPOEPXLPOPDE7A | |
| SCHEMBL30296029 | 0.81 | MPO (0.54) | MPOTPOEPXLPOKDM4E | |
| SCHEMBL4318630 | 0.78 | PDE7A (0.63) | PDE7AHTR2ASLC6A4KDM4EPNLIP | |
| SCHEMBL4797494 | 0.78 | GRM4 (0.51) | MPOTPOEPXLPOPDE7A | |
| SCHEMBL29610975 | 0.77 | ALDH1A1 (0.56) | KDM4EPOLBMEN1KMT2ACYP3A4 | |
| SCHEMBL16345377 | 0.77 | ALDH1A1 (0.56) | KDM4EPOLBMEN1KMT2ACYP3A4 | |
| SCHEMBL5571120 | 0.76 | PDE7A (0.61) | PDE7AKDM4EMEN1KMT2ACYP3A4 | |
| SCHEMBL554722 | 0.75 | MAOA (0.61) | PDE7AHTR2ASLC6A4KDM4EPNLIP | |
| SCHEMBL29553590 | 0.75 | MAOA (0.61) | PDE7AHTR2ASLC6A4KDM4EPNLIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070232607-A1 | Quinazoline Derivatives as Erbb Receptor Tyrosine kinases | BRADBURY ROBERT H | 2007-10-04 | — | — | US | disclosed |
| EP-1756088-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005118572-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070232607-A1 | Quinazoline Derivatives as Erbb Receptor Tyrosine kinases | ERBB2, ERBB3, ERBB4 | MPO 3310/4885TPO 2301/4885EPX 1329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.