Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31035962 | 0.93 | KMT2A (0.57) | TP53SMN1; SMN2KMT2AMEN1USP2 | |
| SCHEMBL15985650 | 0.89 | HDAC2 (0.51) | TP53SMN1; SMN2KMT2AMEN1DRD2 | |
| SCHEMBL6196093 | 0.87 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2KMT2AMEN1DRD2 | |
| SCHEMBL5230823 | 0.86 | SMN1; SMN2 (0.56) | TP53SMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL20998566 | 0.85 | USP2 (0.56) | TP53SMN1; SMN2KMT2AUSP2ALDH1A1 | |
| SCHEMBL18628073 | 0.84 | SMN1; SMN2 (0.58) | TP53SMN1; SMN2KMT2AUSP2ALDH1A1 | |
| SCHEMBL23707785 | 0.83 | SMN1; SMN2 (0.57) | TP53SMN1; SMN2KMT2AUSP2ALDH1A1 | |
| SCHEMBL8433585 | 0.83 | ALDH1A1 (0.66) | SMN1; SMN2ALDH1A1PAOXKDM4E | |
| SCHEMBL11555 | 0.83 | TP53 (0.53) | TP53SMN1; SMN2KMT2AMEN1USP2 | |
| SCHEMBL8437935 | 0.82 | FAAH (0.55) | TP53SMN1; SMN2KMT2AUSP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756088-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2007-02-28 | — | — | EP | claimed |
| WO-2005118572-A1 | QUINAZOLINE DERIVATIVES AS ERBB RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2005-12-15 | — | — | WO | claimed |
| WO-2019165229-A1 | SMALL MOLECULES FOR INDUCING SELECTIVE PROTEIN DEGRADATION AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-08-29 | — | — | WO | disclosed |
| WO-2017044849-A1 | CYANO THIENOTRIAZOLODIAZEPINES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2017-03-16 | — | — | WO | disclosed |