Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929611 | 0.80 | EPAS1 (0.45) | PTGS2PTGS1EPAS1ALOX5APFEN1 | |
| SCHEMBL2395063 | 0.78 | PTGS2 (0.44) | PTGS2PTGS1EPAS1ALOX5APFEN1 | |
| SCHEMBL3929614 | 0.78 | EPAS1 (0.44) | PTGS2PTGS1EPAS1ALDH1A1SLC6A4 | |
| SCHEMBL4637513 | 0.74 | PTGS2 (0.43) | PTGS2PTGS1EPAS1ALOX5APFEN1 | |
| SCHEMBL1333674 | 0.73 | PTGDR2 (0.58) | — | |
| SCHEMBL2397557 | 0.73 | CHRM1 (0.51) | PTGS2SLC6A4 | |
| SCHEMBL4637412 | 0.72 | PTGS2 (0.43) | PTGS2PTGS1EPAS1SMN1; SMN2 | |
| SCHEMBL3930206 | 0.72 | PTGS2 (0.50) | PTGS2PTGS1EPAS1ALOX5APFEN1 | |
| SCHEMBL1333655 | 0.72 | PPARA (0.46) | PTGS2EPAS1SLC6A4 | |
| SCHEMBL3930211 | 0.71 | PTGS2 (0.49) | PTGS2PTGS1EPAS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765768-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | claimed |
| WO-2006005909-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2006-01-19 | — | — | WO | claimed |
| EP-1765768-B1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2013-11-06 | — | — | EP | disclosed |
| EP-1765768-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006005909-A1 | SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2006-01-19 | — | — | WO | disclosed |