Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5570083 | 0.74 | PTGS2 (0.47) | PTGS2PTGS1SMN1; SMN2EPAS1ALOX5AP | |
| SCHEMBL23652 | 0.74 | NFE2L2 (0.33) | — | |
| SCHEMBL9499646 | 0.73 | HPGD (0.41) | SMN1; SMN2LMNA | |
| SCHEMBL4637412 | 0.73 | PTGS2 (0.43) | PTGS2PTGS1SMN1; SMN2BRD4PTGDR2 | |
| SCHEMBL5387729 | 0.72 | PTGS2 (0.48) | PTGS2PTGS1SMN1; SMN2BRD4PTGDR2 | |
| SCHEMBL5387735 | 0.71 | PTGS2 (0.47) | PTGS2PTGS1SMN1; SMN2BRD4PTGDR2 | |
| SCHEMBL10950526 | 0.71 | EPAS1 (0.52) | PTGS2PTGS1EPAS1LMNACYP11B1 | |
| SCHEMBL5397099 | 0.71 | PTGS2 (0.46) | PTGS2PTGS1SMN1; SMN2BRD4PTGDR2 | |
| SCHEMBL4637503 | 0.70 | EPAS1 (0.49) | PTGS2PTGS1SMN1; SMN2PTGDR2EPAS1 | |
| SCHEMBL5789256 | 0.70 | PTGS2 (0.46) | PTGS2PTGS1SMN1; SMN2PTGDR2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |