Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 13/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ABAT | P80404 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10509367 | 0.80 | TAAR1 (0.61) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL9636344 | 0.80 | TAAR1 (0.61) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL14998954 | 0.78 | TAAR1 (0.58) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL8931393 | 0.76 | TAAR1 (0.62) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL11563760 | 0.76 | TRPA1 (0.50) | TAAR1 | |
| SCHEMBL450874 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL7166607 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL15928032 | 0.76 | TAAR1 (0.56) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL14541035 | 0.75 | SLC7A5 (0.60) | TAAR1SLC6A2ESR1ESR2SLC7A5 | |
| SCHEMBL14540739 | 0.75 | SLC7A5 (0.60) | TAAR1SLC6A2ESR1ESR2SLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3818054-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Les Laboratoires Servier (FR) | 2021-05-12 | — | — | EP | disclosed |
| CN-112368276-A | Amino-pyrimidinone derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2021-02-12 | — | — | CN | disclosed |
| WO-2020008013-A1 | AMINO-PYRIMIDONYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2020-01-09 | — | — | WO | disclosed |
| EP-1814849-A1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | Abbott GmbH & Co. KG (DE) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006040182-A1 | HETEROCYCLIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR | ABBOTT GMBH & CO. KG (DE) | 2006-04-20 | — | — | WO | disclosed |