Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032618 | 0.82 | F2 (0.50) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL5032675 | 0.82 | ALDH1A1 (0.53) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL5571722 | 0.82 | CYP2C19 (0.43) | F2PRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL2018411 | 0.77 | LMNA (0.69) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL29973441 | 0.77 | LMNA (0.69) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL5568746 | 0.74 | CYP19A1 (0.55) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL5566217 | 0.72 | POLB (0.57) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL687474 | 0.71 | LMNA (0.61) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL12334829 | 0.71 | ALDH1A1 (0.53) | F2PRSS1PRSS2PRSS3CYP19A1 | |
| SCHEMBL452006 | 0.71 | PRMT1 (0.66) | F2PRSS1PRSS2PRSS3CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123738-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | disclosed |