Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 6/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5032668 | 0.84 | ALDH1A1 (0.50) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5032686 | 0.84 | CYP2C19 (0.45) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5571728 | 0.82 | F2 (0.48) | F2PRSS1PRSS2PRSS3CA1 | |
| SCHEMBL5041352 | 0.80 | LMNA (0.61) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5566210 | 0.76 | CA1 (0.56) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28208130 | 0.76 | ADAMTS4 (0.50) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL2854385 | 0.75 | LMNA (0.56) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2850555 | 0.75 | LMNA (0.53) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5041380 | 0.74 | CYP2C19 (0.49) | CYP2C19HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5034887 | 0.73 | CYP2C19 (0.76) | CYP2C19HDAC2HDAC8HDAC6PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761541-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2007-03-14 | — | — | EP | disclosed |
| WO-2005123738-A1 | PYRRAZOLO-PYRIMIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2005-12-29 | — | — | WO | disclosed |