SCHEMBL5571807

SCHEMBL5571807

[C]#Cc1ccc(F)c2cc(CCCC)cnc12

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 4/20 0.34
PKM P14618 2/20 0.34
L3MBTL1 Q9Y468 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
MAPT P10636 1/20 0.34
ALOX15 P16050 1/20 0.34
TSHR P16473 1/20 0.34
THPO P40225 1/20 0.34
BLM P54132 1/20 0.34
PMP22 Q01453 1/20 0.34
KMT2A Q03164 1/20 0.34
HIF1A Q16665 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
NPC1 O15118 4/20 0.33
RAB9A P51151 4/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL738966 0.87 NFKB1 (0.34) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL737012 0.83 LYN (0.34) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL740066 0.80 NPC1 (0.40) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL738208 0.77 KDM4E (0.30) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL738209 0.76
SCHEMBL11726118 0.69 NPC1 (0.41) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL21988090 0.67 RAB9A (0.40) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL31026571 0.67 NPC1 (0.45) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL10728895 0.66 RARB (0.50) NFKB1PKML3MBTL1KDM4EMEN1
SCHEMBL8774481 0.65 NFKB1 (0.44) NFKB1PKML3MBTL1KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101111499-B Substituted ethynyl gold-nitrogen-containing heterocyclic carbene complex and organic electroluminescent device using the same UBE INDUSTRIES 2012-05-23 CN disclosed
CN-101111499-A Substituted ethynyl gold-nitrogenated heterocyclic carbene complex and organic electroluminescent device using same UBE INDUSTRIES (JP) 2008-01-23 CN disclosed
EP-1847545-A1 SUBSTITUTED ETHYNYL GOLD-NITROGENATED HETEROCYCLIC CARBENE COMPLEX AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME Ube Industries, Ltd. (JP) 2007-10-24 EP disclosed