Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8774784 | 0.95 | RAB9A (0.46) | NFKB1L3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8774239 | 0.94 | HTR2A (0.50) | L3MBTL1ALDH1A1KDM4EMEN1MAPT | |
| SCHEMBL8774406 | 0.91 | RARB (0.50) | NFKB1L3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8775147 | 0.90 | NPC1 (0.47) | MAPTPKMSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL8774178 | 0.88 | CYP3A4 (0.43) | L3MBTL1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8774752 | 0.86 | TAAR1 (0.44) | L3MBTL1ALDH1A1KDM4EPKMLMNA | |
| SCHEMBL8774337 | 0.85 | RAB9A (0.50) | NFKB1L3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8774858 | 0.85 | MEN1 (0.44) | L3MBTL1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8774086 | 0.84 | RARB (0.49) | NFKB1L3MBTL1ALDH1A1KDM4EMEN1 | |
| SCHEMBL8774800 | 0.84 | RARB (0.49) | NFKB1L3MBTL1ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519370-B1 | Heterocyclic derivatives | MERCK PATENT GMBH (DE) | 1997-11-05 | — | — | EP | disclosed |
| EP-0519370-A2 | Heterocyclic derivatives | MERCK PATENT GmbH (DE) | 1992-12-23 | — | — | EP | disclosed |