Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA4 | P22748 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13446220 | 0.83 | MAPT (0.40) | ALDH1A1TDP1L3MBTL1MAPTLMNA | |
| SCHEMBL14341653 | 0.82 | HPGD (0.46) | ALDH1A1L3MBTL1MAPTLMNAHPGD | |
| SCHEMBL4260934 | 0.81 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1MAPTKDM4EKMT2A | |
| SCHEMBL10633601 | 0.79 | ALDH1A1 (0.43) | ALDH1A1TDP1TAS1R3TAS1R1TSHR | |
| SCHEMBL6038269 | 0.76 | HPGD (0.38) | ALDH1A1L3MBTL1MAPTLMNAHPGD | |
| SCHEMBL14367054 | 0.75 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1MAPTLMNAHPGD | |
| SCHEMBL23188557 | 0.74 | ALDH1A1 (0.37) | ALDH1A1TDP1TAS1R3TAS1R1HDAC8 | |
| SCHEMBL24306252 | 0.74 | NPC1 (0.52) | ALDH1A1TDP1TSHRHDAC8MAPT | |
| SCHEMBL6208993 | 0.73 | NR1H2 (0.48) | ALDH1A1TSHRL3MBTL1MAPTLMNA | |
| SCHEMBL7518002 | 0.73 | MAPT (0.50) | ALDH1A1TDP1L3MBTL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7226906-B2 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA, INC. (US) | 2007-06-05 | — | — | US | disclosed |
| WO-2006023452-A2 | CYCLOSPORIN ANALOGS FOR THE TREATMENT OF IMMUNOREGULATORY DISORDERS AND RESPIRATORY DISEASES | ARRAY BIOPHARMA INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060035822-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
| US-20060035821-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. | 2006-02-16 | — | — | US | disclosed |
| EP-0271307-B1 | METHOD FOR PRODUCING ALKENYLTHIOPHENOLS AND THEIR ESTERS | HOECHST CELANESE CORPORATION (US) | 1992-01-02 | — | — | EP | disclosed |
| EP-0396413-A2 | Copolymers of P-mercaptostyrene and its esters | HOECHST CELANESE CORPORATION (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4929694-A | COPOLYMERS WITH STYRENE, N-METHYL MALEIMIDE, SEQUESTERING | HOECHST CELANESE CORPORATION (US) | 1990-05-29 | — | — | US | disclosed |
| US-4794205-A | Method for producing alkenylthiophenols and their esters | HOECHST CELANESE CORPORATION (US) | 1988-12-27 | — | — | US | disclosed |
| EP-0271307-A2 | Method for producing alkenylthiophenols and their esters | HOECHST CELANESE CORPORATION (US) | 1988-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035821-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | TSLP, CHP1, IL2 | ALDH1A1 3651/4885TDP1 2616/4885TAS1R3 3539/4885 |
| US-20060035822-A1 | Cyclosporin analogs for the treatment of immunoregulatory disorders and respiratory diseases | TSLP, CHP1, IL2 | ALDH1A1 3651/4885TDP1 2616/4885TAS1R3 3539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.