Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306266 | 0.86 | SMN1; SMN2 (0.47) | SMN1; SMN2MAP2K1ALDH1A1APPGAA | |
| SCHEMBL15268207 | 0.80 | KCNMA1 (0.48) | SMN1; SMN2MAP2K1ALDH1A1GAAMEN1 | |
| SCHEMBL305749 | 0.79 | MAPT (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3409177 | 0.74 | ALDH1A1 (0.50) | SMN1; SMN2MAP2K1ALDH1A1APPGAA | |
| SCHEMBL15646031 | 0.72 | PKM (0.64) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| SCHEMBL1242243 | 0.72 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL29915528 | 0.72 | ALDH1A1 (0.71) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL6665398 | 0.72 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1APPGAAHCAR3 | |
| Hydrochloric Acid SCHEMBL27841975 | 0.70 | ALDH1A1 (0.68) | MAP2K1ALDH1A1APPGAAHCAR3 | |
| SCHEMBL18228667 | 0.70 | ALDH1A1 (0.49) | SMN1; SMN2MAP2K1ALDH1A1APPGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838674-A2 | HETEROARYL SULFONAMIDES AND CCR2 | ChemoCentryx Inc (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006076644-A2 | HETEROARYL SULFONAMIDES AND CCR2 | CHEMOCENTRYX, INC. (US) | 2006-07-20 | — | — | WO | disclosed |