Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.58 |
| ▸ | P2RX1 | P51575 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | TACR1 | P25103 | 1/20 | 0.51 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.51 |
| ▸ | IKBKB | O14920 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14015103 | 0.87 | MAPT (0.57) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL5108428 | 0.87 | GPR35 (0.50) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL23148069 | 0.84 | MAPT (0.62) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL26634741 | 0.84 | MAPT (0.58) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL2681462 | 0.83 | MAPT (0.78) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL7692960 | 0.83 | GPR35 (0.74) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL5119432 | 0.82 | NOTUM (0.59) | MAPTGPR35P2RX1LMNAMEN1 | |
| SCHEMBL2883710 | 0.81 | MAPT (0.68) | MAPTP2RX1LMNAMEN1KMT2A | |
| SCHEMBL26639301 | 0.81 | MAPT (0.54) | MAPTGPR35P2RX1LMNAACP1 | |
| SCHEMBL11788448 | 0.81 | MAPT (0.63) | MAPTGPR35P2RX1LMNAACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230337677-A1 | ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED | 2023-10-26 | — | — | US | disclosed |
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | EXELIXIS, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| EP-1608373-A2 | TIE-2 MODULATORS AND METHODS OF USE | Exelixis Inc. (US) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004083235-A2 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS INC. (US) | 2004-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275952-A1 | Tie-2 Modulators and Methods of Use | TIE1, TEK, KDR | MAPT 2716/4885GPR35 2890/4885P2RX1 2045/4885 |
| US-20230337677-A1 | ARYL AND PYRIDYL AMIDE PESTICIDES AND COMPOSITIONS THEREOF | DDT, ACHE, AHR | MAPT 1631/4885GPR35 1183/4885P2RX1 565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.