Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | EBP | Q15125 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5573856 | 0.88 | HTT (0.41) | OPRM1MDM2ATMHTTEBP | |
| SCHEMBL5569403 | 0.80 | OPRM1 (0.50) | OPRM1EBPSIGMAR1 | |
| SCHEMBL9037683 | 0.73 | SIGMAR1 (0.49) | OPRM1EBPSIGMAR1 | |
| SCHEMBL9040998 | 0.72 | SIGMAR1 (0.47) | OPRM1EBPSIGMAR1 | |
| SCHEMBL9040061 | 0.72 | SIGMAR1 (0.50) | OPRM1EBPSIGMAR1 | |
| SCHEMBL29635337 | 0.71 | MAPK1 (0.40) | OPRM1SMN1; SMN2 | |
| SCHEMBL5573928 | 0.70 | OPRM1 (0.42) | OPRM1MDM2SIGMAR1 | |
| SCHEMBL30472318 | 0.68 | MAPK1 (0.39) | LMNANPSR1HTTSMN1; SMN2SIGMAR1 | |
| SCHEMBL9831147 | 0.68 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL6589626 | 0.67 | RXFP1 (0.50) | OPRM1LMNANPSR1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-A1 | ISOINDOLIN-1-ONE DERIVATIVES | Cancer Research Technology Limited (GB) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |