Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fentanyl. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.58 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.58 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.58 |
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.58 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.58 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fentanyl SCHEMBL6002326 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL6908995 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL40733 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL216836 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL193602 | 0.85 | OPRM1 (0.80) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL27481710 | 0.84 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL19066928 | 0.84 | OPRM1 (0.78) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL2722646 | 0.82 | OPRM1 (0.74) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL1773864 | 0.82 | OPRM1 (0.66) | OPRM1OPRD1OPRK1SLC22A1NR1I2 | |
| Fentanyl SCHEMBL916599 | 0.76 | OPRM1 (1.00) | OPRM1OPRD1OPRK1SLC22A1NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545462-A4 | DENDRIMERS AS MOLECULAR TRANSLOCATORS | UNIV CALIFORNIA (US) | 2007-08-08 | — | — | EP | disclosed |
| EP-1545462-A2 | DENDRIMERS AS MOLECULAR TRANSLOCATORS | The Regents of the University of California (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004009666-A2 | DENDRIMERS AS MOLECULAR TRANSLOCATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-01-29 | — | — | WO | disclosed |
| WO-2004009665-A2 | DENDRIMERS AS MOLECULAR TRANSLOCATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-01-29 | — | — | WO | disclosed |