Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.50 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.50 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL4127642 | 0.82 | GSK3A (0.58) | GSK3AGSK3BCCR6OR51E2TSHR | |
| Glycolic Acid SCHEMBL29471409 | 0.82 | GSK3A (0.58) | GSK3AGSK3BCCR6CA12CA9 | |
| Carbamic Acid SCHEMBL6022388 | 0.81 | GSK3A (0.65) | GSK3AGSK3BCCR6TSHR | |
| Ethylenediamine SCHEMBL8736497 | 0.81 | GSK3A (0.73) | GSK3AGSK3BCCR6 | |
| Bicarbonate SCHEMBL5071661 | 0.81 | GSK3A (0.73) | GSK3AGSK3BCCR6CA9KDM4E | |
| Propionic Acid SCHEMBL264767 | 0.80 | GSK3A (0.55) | GSK3AGSK3BCCR6CA12CA9 | |
| Thioglycolic Acid SCHEMBL2267919 | 0.80 | GSK3A (0.55) | GSK3AGSK3BCCR6CA12CA9 | |
| Chloroacetic Acid SCHEMBL28991877 | 0.80 | GSK3B (0.55) | GSK3AGSK3BCCR6CA12CA9 | |
| Iodoacetic Acid SCHEMBL27515253 | 0.80 | GSK3A (0.55) | GSK3AGSK3BCCR6CA12CA9 | |
| Urea SCHEMBL8556796 | 0.78 | GSK3A (0.69) | GSK3AGSK3BCCR6OR51E2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240216525-A1 | ENZYME-TRIGGERED SELF-REACTING LINKER HAVING IMPROVED PHYSICOCHEMICAL AND PHARMACOLOGICAL PROPERTIES | MABLINK BIOSCIENCE (FR) | 2024-07-04 | — | — | US | disclosed |
| EP-4313157-A1 | ENZYME-TRIGGERED SELF-REACTING LINKER HAVING IMPROVED PHYSICOCHEMICAL AND PHARMACOLOGICAL PROPERTIES | Mablink Bioscience (FR) | 2024-02-07 | — | — | EP | disclosed |
| CN-117157102-A | Enzyme-triggered self-reacting linkers with improved physicochemical and pharmacological properties | 马布林克生物科学公司 | 2023-12-01 | — | — | CN | disclosed |
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-02-09 | — | — | US | disclosed |
| CN-102216779-A | Method for the preparation of immunoconjugates and use thereof | XEPTAGEN SPA | 2011-10-12 | — | — | CN | disclosed |
| EP-0847991-A1 | Method for the preparation of N-(carboxyalkyl) imides | DAINIPPON INK AND CHEMICALS, INC. (JP) | 1998-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035320-A1 | POLYACRIDINE NUCLEIC ACID DELIVERY PEPTIDE COMPLEXES | NUP205, PABPC1, SARNP | GSK3A 4791/4885GSK3B 4825/4885CCR6 481/4885 |
| US-20240216525-A1 | ENZYME-TRIGGERED SELF-REACTING LINKER HAVING IMPROVED PHYSICOCHEMICAL AND PHARMACOLOGICAL PROPERTIES | DDC, BCHE, ENGASE | GSK3A 1610/4885GSK3B 1527/4885CCR6 2040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.