SCHEMBL557383

SCHEMBL557383

O=c1[nH]ccc2nccn12

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 3/20 0.44
CCNE1 P24864 12/20 0.42
CDK2 P24941 12/20 0.42
CCNE2 O96020 4/20 0.41
ADORA3 P0DMS8 1/20 0.40
CHEK1 O14757 1/20 0.38
MAP4K4 O95819 1/20 0.38
CSF1R P07333 1/20 0.38
PRKACA P17612 1/20 0.38
KDR P35968 1/20 0.38
CDK8 P49336 1/20 0.38
ACVR1 Q04771 1/20 0.38
MAP4K2 Q12851 1/20 0.38
ROCK1 Q13464 1/20 0.38
DYRK1A Q13627 1/20 0.38
AURKB Q96GD4 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
CCNT1 O60563 1/20 0.37
CDK1 P06493 1/20 0.37
CDK4 P11802 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19410802 0.76 CDK8 (0.38) MAP2K1ADORA3CHEK1MAP4K4CSF1R
SCHEMBL29242590 0.69 BRD4 (0.45) MAP2K1ADORA3CHEK1MAP4K4CSF1R
SCHEMBL7700737 0.68 PDE3B (0.39) MAP2K1CCNE1CDK2CCNE2ADORA3
SCHEMBL19152456 0.68 CCNE1 (0.42) CCNE1CDK2CCNE2ADORA3CCNT1
SCHEMBL30473299 0.68 ADORA3 (0.36) CCNE1CDK2CCNE2ADORA3CCNT1
SCHEMBL124346 0.68 ADORA3 (0.44) MAP2K1CCNE1CDK2CCNE2ADORA3
SCHEMBL557300 0.67 GRIN2D (0.41) CCNE1CDK2CCNE2ADORA3PDE3B
SCHEMBL18439086 0.65 MAP2K1 (0.57) MAP2K1ADORA3DYRK1ADYRK1B
SCHEMBL13936549 0.65 ADORA3 (0.41) MAP2K1CCNE1CDK2ADORA3CHEK1
SCHEMBL2643830 0.65 XDH (0.41) CCNE1CDK2CCNE2CCNT1CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3538 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117907112-B Organic glass equivalent acceleration test method based on creep constitutive equation CHINA SHIP SCIENTIFIC RESEARCH CENTER (CN) 2026-05-26 CN claimed
CN-118070278-B Federal learning back door attack defense method and system CHONGQING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS (CN) 2026-05-26 CN claimed
CN-121682053-B Wavelet kernel scale sensitivity oriented abrasive grain induced voltage signal noise reduction method CHONGQING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS (CN) 2026-05-26 CN claimed
CN-122046471-A Lining construction monitoring method meeting requirement of TBM station crossing for extra-large section underground excavation station 中国水利水电第六工程局有限公司 2026-05-15 CN claimed
CN-122047578-A Cluster distributed decision-making method and simulation system under limited observation condition 中国融通集团第六十研究所 2026-05-15 CN claimed
CN-122023717-A Historical building group visual integrity quantitative measurement method 东南大学 2026-05-12 CN claimed
CN-122017214-A Device and method for testing curing shrinkage of component polymer packaging material 桂林电子科技大学 2026-05-12 CN claimed
CN-122017804-A Multi-sensor joint calibration method and system based on scale compensation 广智微芯(扬州)有限公司 2026-05-12 CN claimed
US-20260098287-A1 METHOD AND KIT FOR REGENERATING REUSABLE INITIATORS FOR NUCLEIC ACID SYNTHESIS CHENG-YAO CHEN (TW) 2026-04-09 US claimed
CN-121574384-A Double-layer hydrogel for pressure distribution identification and preparation method and application thereof 安徽理工大学 2026-02-27 CN claimed
CN-110794578-B Illusion device with two-layer columnar structure 金陵科技学院 2022-02-11 CN claimed
CN-114018711-A Method for determining change of concrete elastic modulus and shrinkage strain along with time 中冶建筑研究总院有限公司 2022-02-08 CN claimed
CN-110232252-B Heat exchange power design method for cooling system of ultrasonic transducer in aluminum melt composite degassing device 哈尔滨理工大学 2022-02-08 CN claimed
CN-113219840-B Self-adaptive sliding mode cross-coupling contour control method for three-axis motion platform 西安文理学院 2022-02-01 CN claimed
CN-111187649-B Trimellitate lubricating oil base oil based on block polyester chemical modification and preparation method thereof 新疆工程学院 2022-01-28 CN claimed
CN-113959628-A Blast furnace upper pressure distribution and furnace condition determination method 攀钢集团研究院有限公司 2022-01-21 CN claimed
US-20150211004-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2015-07-30 US claimed
EP-2838541-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES Agency For Science, Technology And Research (SG) 2015-02-25 EP claimed
WO-2013158046-A1 RNAI-BASED THERAPIES FOR CARDIOMYOPATHIES, MUSCULAR DYSTROPHIES AND LAMINOPATHIES AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2013-10-24 WO claimed
EP-0185346-A2 Imidazo derivatives, their preparation and medicaments containing these compounds Dr. Karl Thomae GmbH (DE) 1986-06-25 EP claimed