Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540873 | 0.84 | KDM4E (0.42) | MAPTALOX15ALDH1A1KDM4ENPC1 | |
| SCHEMBL5501828 | 0.83 | MAPT (0.43) | MAPTALOX15TP53ALDH1A1KDM4E | |
| SCHEMBL4022950 | 0.78 | ALDH1A1 (0.51) | MAPTNR1H4TP53ALDH1A1KDM4E | |
| SCHEMBL5271016 | 0.76 | ALDH1A1 (0.49) | MAPTNR1H4TP53ALDH1A1KDM4E | |
| SCHEMBL5504444 | 0.75 | KDM4E (0.40) | MAPTALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL5573437 | 0.73 | KDM4E (0.38) | MAPTKDM4ENPC1RAB9APOLB | |
| SCHEMBL5574783 | 0.73 | KDM4E (0.44) | MAPTALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL5517754 | 0.72 | POLB (0.36) | MAPTNR1H4TP53THRBALDH1A1 | |
| SCHEMBL5571405 | 0.72 | KDM4E (0.43) | MAPTALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL5570203 | 0.72 | KDM4E (0.43) | MAPTALDH1A1KDM4EHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841736-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006077367-A1 | INDOLES USEFUL IN THE TREATMENT OF INFLAMATION | BIOLIPOX AB (SE) | 2006-07-27 | — | — | WO | disclosed |