⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718568 | 1.00 | — | — | |
| SCHEMBL9811639 | 0.82 | LMNA (0.53) | — | |
| SCHEMBL17200647 | 0.82 | LMNA (0.53) | — | |
| SCHEMBL14937404 | 0.80 | LMNA (0.58) | — | |
| SCHEMBL23647592 | 0.80 | LMNA (0.58) | — | |
| SCHEMBL8768308 | 0.75 | LMNA (0.42) | — | |
| SCHEMBL6373695 | 0.73 | — | — | |
| SCHEMBL10427686 | 0.71 | — | — | |
| SCHEMBL10427707 | 0.71 | — | — | |
| SCHEMBL667678 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070244055-A1 | Conjugates useful in the treatment of prostate cancer | BRADY STEPHEN F | 2007-10-18 | — | — | US | disclosed |
| US-20070129309-A1 | Conjugates useful in the treatment of prostate cancer | BRADY STEPHEN F | 2007-06-07 | — | — | US | disclosed |
| US-20070021350-A1 | Conjugates useful in the treatment of prostate cancer | BRADY STEPHEN F | 2007-01-25 | — | — | US | disclosed |
| US-20060148718-A1 | Conjugates useful in the treatment of prostate cancer | BRADY STEPHEN F | 2006-07-06 | — | — | US | disclosed |
| EP-1545572-A4 | CONJUGATES ACTIVATED BY CELL SURFACE PROTEASES AND THERAPEUTIC USES THEREOF | DENDREON CORP (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1545572-A2 | CONJUGATES ACTIVATED BY CELL SURFACE PROTEASES AND THERAPEUTIC USES THEREOF | Dendreon Corporation (US) | 2005-06-29 | — | — | EP | disclosed |
| US-20050119166-A1 | Conjugates useful in the treatment of prostate cancer | BRADY STEPHEN F (US) | 2005-06-02 | — | — | US | disclosed |
| US-20040081659-A1 | Conjugates useful in the treatment of prostate cancer | MERCK & CO., INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040058857-A1 | Method of treating cancer | YAO SIU-LONG (US) | 2004-03-25 | — | — | US | disclosed |
| US-20040001801-A1 | Conjugates activated by cell surface proteases and therapeutic uses thereof | CORVAS INTERNATIONAL, INC. | 2004-01-01 | — | — | US | disclosed |
| EP-1036093-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | Merck & Co., Inc. (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1009420-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | Merck & Co., Inc. (US) | 2000-06-21 | — | — | EP | disclosed |
| US-5998362-A | OLIGOPEPTIDES, HAVING AMINO ACID SEQUENCES THAT ARE SELECTIVELY PROTEOLYTICALLY CLEAVED BY FREE PROSTATE SPECIFIC ANTIGEN (PSA), HYDROPHILIC OLIGOPEPTIDE BLOCKING GROUPS | MERCK & CO., INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0942754-A2 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | Merck & Co., Inc. (US) | 1999-09-22 | — | — | EP | disclosed |
| US-5948750-A | OLIGOPEPTIDES, HAVING AMINO ACID SEQUENCES THAT ARE SELECTIVELY PROTEOLYTICALLY CLEAVED BY FREE PROSTATE SPECIFIC ANTIGEN (PSA) AND KNOWN CYTOTOXIC AGENTS ARE DISCLOSED. SUCH CONJUGATES ARE USEFUL IN THE TREATMENT OF PROSTATIC CANCER AND | MERCK & CO., INC. (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0926955-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | Merck & Co., Inc. (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1999028345-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO., INC. (US) | 1999-06-10 | — | — | WO | disclosed |
| WO-1999002175-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO., INC. (US) | 1999-01-21 | — | — | WO | disclosed |
| WO-1998018493-A2 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO., INC. (US) | 1998-05-07 | — | — | WO | disclosed |
| WO-1998010651-A1 | CONJUGATES USEFUL IN THE TREATMENT OF PROSTATE CANCER | MERCK & CO., INC. (US) | 1998-03-19 | — | — | WO | disclosed |