Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | SCN4A | P35499 | 2/20 | 0.40 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484948 | 0.86 | TSHR (0.46) | LMNAMAPTMEN1ADORA1KMT2A | |
| SCHEMBL1897605 | 0.84 | S1PR5 (0.49) | S1PR5S1PR1RORCSCN4A | |
| SCHEMBL13041176 | 0.84 | S1PR5 (0.49) | S1PR5S1PR1RORCSCN4A | |
| SCHEMBL27042490 | 0.82 | PRMT1 (0.50) | LMNAMEN1KMT2AS1PR5S1PR1 | |
| SCHEMBL30728803 | 0.82 | PRMT1 (0.50) | LMNAMEN1KMT2AS1PR5S1PR1 | |
| SCHEMBL30728773 | 0.82 | PRMT1 (0.50) | LMNAMEN1KMT2AS1PR5S1PR1 | |
| SCHEMBL1896746 | 0.81 | USP30 (0.51) | S1PR5S1PR1USP30SMN1; SMN2RORC | |
| SCHEMBL4480859 | 0.80 | MAPT (0.41) | LMNAMAPTMEN1ADORA1KMT2A | |
| SCHEMBL852497 | 0.80 | S1PR5 (0.44) | S1PR5S1PR1USP30RORCSIGMAR1 | |
| SCHEMBL4465368 | 0.76 | FAAH (0.43) | MEN1KMT2AS1PR5S1PR1RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778225-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006019886-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |