Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809109 | 0.88 | L3MBTL1 (0.41) | S1PR5S1PR1SIGMAR1USP30RORC | |
| SCHEMBL1809107 | 0.88 | L3MBTL1 (0.41) | S1PR5S1PR1SIGMAR1USP30RORC | |
| SCHEMBL4484948 | 0.82 | TSHR (0.46) | S1PR5S1PR1SIGMAR1USP30RORC | |
| SCHEMBL1897605 | 0.80 | S1PR5 (0.49) | S1PR5S1PR1RORCALDH1A1 | |
| SCHEMBL13041176 | 0.80 | S1PR5 (0.49) | S1PR5S1PR1RORCALDH1A1 | |
| SCHEMBL5575775 | 0.80 | LMNA (0.45) | S1PR5S1PR1SIGMAR1USP30RORC | |
| SCHEMBL1805174 | 0.80 | L3MBTL1 (0.43) | S1PR5S1PR1SIGMAR1L3MBTL1 | |
| SCHEMBL1805177 | 0.80 | L3MBTL1 (0.43) | S1PR5S1PR1SIGMAR1L3MBTL1 | |
| SCHEMBL1805170 | 0.80 | L3MBTL1 (0.43) | S1PR5S1PR1SIGMAR1L3MBTL1 | |
| SCHEMBL1896746 | 0.77 | USP30 (0.51) | S1PR5S1PR1SIGMAR1USP30RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2571353-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2013-03-27 | — | — | EP | disclosed |
| EP-2432783-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2011146089-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-11-24 | — | — | WO | disclosed |
| WO-2010135560-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-11-25 | — | — | WO | disclosed |