Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 3/20 | 0.35 |
| ▸ | KDM1A | O60341 | 3/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556873 | 0.83 | ADAMTS5 (0.33) | HTR2AHTR2CHTR2BADAMTS5KDM1A | |
| SCHEMBL556600 | 0.80 | ADAMTS5 (0.32) | HTR2AHTR2CHTR2BADAMTS5KDM1A | |
| SCHEMBL556475 | 0.71 | HTR2A (0.44) | HTR2AHTR2CHTR2BADAMTS5KDM1A | |
| SCHEMBL555599 | 0.71 | SLC6A2 (0.32) | NTRK1SLC6A2SLC6A3FFAR2 | |
| SCHEMBL14920363 | 0.71 | ADAMTS5 (0.43) | HTR2AHTR2CHTR2BADAMTS5KDM1A | |
| SCHEMBL30569759 | 0.68 | KDM1A (0.37) | HTR2AHTR2CHTR2BADAMTS5KDM1A | |
| SCHEMBL14934624 | 0.67 | PDE4B (0.53) | ADAMTS5PDE4B | |
| SCHEMBL16141292 | 0.67 | PDE4B (0.53) | ADAMTS5PDE4B | |
| SCHEMBL14921796 | 0.67 | PDE4B (0.53) | ADAMTS5PDE4B | |
| SCHEMBL14921794 | 0.67 | PDE4B (0.53) | ADAMTS5PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | MERCK CANADA INC. (CA) | 2012-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035214-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | HTR2A 3006/4885HTR2C 2629/4885HTR2B 3136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.